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We hypothesised that certain medications used by these patients may have influenced the development of advanced fibrosis in NAFLD patients with DM, as has been observed in other chronic liver disease.The use of Angiotensinogen Converting Enzyme Inhibitor (ACE-I) was observed to reduce the risk of advanced fibrosis in chronic hepatitis C patients .
The use of insulin (OR 4.95; 95%CI 1.65-14.88, p=0.004) and sulfonylurea (OR 5.07; 95%CI 1.87-13.75, p=0.001) were positively associated while statin use (OR 0.31; 95%CI 0.12-0.78, p=0.013) was negatively associated with advanced fibrosis.
Conclusion: Among non-alcoholic fatty liver disease patients with diabetes, the prevalence of advanced fibrosis was higher in patients treated with insulin and sulfonylurea, but lower in patients on statins.
We hypothesised that prescription medications used by these patients influence the development of advanced fibrosis.
We investigated the association of commonly used medications and advanced fibrosis in non-alcoholic fatty liver disease patients with diabetes.
Only clinical data obtained within 6 months of the corresponding liver biopsy were included.
A careful medication history focused on the use of insulin, metformin, sulfonylurea, hydroxyl-methylglutaryl-coenzyme A reductase inhibitors (statins) and angiotensin converting enzyme inhibitor (ACE-I)/Angiotensin II Receptor Blocker (ARB) because these agents have been shown to affect insulin resistance, hepatic lipid metabolism or fibrosis.
Patients with other potential contributory causes of liver disease (alcohol consumption [14 drinks per week for males and females respectively], hepatotoxic drug history, chronic viral hepatitis, hemochromatosis, autoimmune hepatitis, Wilson’s disease or alpha-1 antitrypsin disease) were excluded .
Study design Demographic and clinical information was gathered from an electronic medical record system that is common to both hospitals.
J Diabetes Metab 0 doi: 10.4172/2155-6156.1000410 Copyright: © 2014 Goh GBB, et al.